Since NASA was established in 1958 by President Eisenhower, the expansion of human knowledge of the Earth and of phenomena in the atmosphere and space has been the priority of NASA. Discovery and exploration occur both with robotic and human exploration and it has changed how we think about the universe, our planet, and life beyond Earth. This presentation will focus on a few recent missions, to demonstrate the power of space as a frontier of discovery, and to show how these missions rely on teams that make the impossible possible. It will particularly focus on commercial and international partnerships that are a critical part of NASA’s Science program.