Département Toxicologie de l’environnement

Projets

Toxicologie des particules et des polymères

Implementing SSbD in practice: Integration of aquatic toxicity considerations into the R&D process for novel flame retardant vitrimers

SSbD-vitrimers
Reifen- und Straßenabriebpartikel (TRWP) entstehen durch die Erosion von Reifen während des Fahrens und machen einen großen Teil der anthropogenen Partikel aus, die in die Umwelt gelangen.

Mechanistische Einblicke in die Toxizität von Reifenpartikeln
CaLIBRAte is part of European Union’s Horizon 2020 research and innovation programme and addresses risk management / governance for assessment of human and environmental risks of manufactured nanomaterials (MN) and MN-enabled products.

caLIBRAte
Particulate plastics (nano- and microplastic particles; size < 5µm) are an extremely persistent pollutant in the environment. As a consequence...

Effects of particulate plastics on stream periphyton and food-webs

Toxicologie computationnelle et modélisation

Data integration, analysis, and visualization will be used to characterize genetic susceptibility to chemical pollution in zebrafish and C. elegans.

Characterizing genetic susceptibility to pesticides
Data integration, network analysis, and computational AOPs will be used to characterize cross-species and cross-chemical mechanisms.

Building a library of chemical toxicity mechanisms
Environmental risk assessment is essential but often relies on ethically controversial and expensive methods...

Physiologically based toxicokinetic modeling
Zellbasierte Technologien in Verbindung mit Extrapolationsmodellen erleichtern die Abschätzung der Bioakkumulation von Chemikalien und verbessern somit die Vorhersage des In-vivo-Niveaus ohne Verwendung von Tieren

Bioakkumulation von Chemikalien anhand zellbasierter Fischmodelle

Alternatives aux expérimentations animales

Implementing SSbD in practice: Integration of aquatic toxicity considerations into the R&D process for novel flame retardant vitrimers

SSbD-vitrimers
Développement d'un modèle basé sur des cellules de poisson pour les tests de neurotoxicité, afin d'améliorer notre compréhension des mécanismes de neurotoxicité et d'explorer des alternatives sans animaux

Modèle in vitro pour les tests de neurotoxicité
Data integration and the AOP framework will be used to predict GxE interactions in pesticide-induced Parkinson disease.

Characterizing gene-environment interactions in human diseases
Data integration, network analysis, and computational AOPs will be used to characterize cross-species and cross-chemical mechanisms.

Building a library of chemical toxicity mechanisms
BIOTRANSFORM: Organ- und artspezifische Biotransformation von aquatischen Mikroverunreinigungen in Fischen

BIOTRANSFORM
We are applying impedance sensing with cell lines of the rainbow trout cultured on microfluidic chips to detect toxic substances in water and test toxicity of chemicals under flow conditions.

RAINBOWflow Chip impedance biosensor
Im Rahmen dieses Projektes streben wir an, das Moderlieschen (Leucaspius delineatus) als Fischmodell innerhalb der Ökotoxikologie und Ökologie zu etablieren...

Moderlieschen als einheimischer Modelorganismus
The project, funded by 3R Research Foundation Switzerland (3R-Project 145-15) aims to develop an animal-free alternative to replace experiments with fish for quantifying the impact of chemicals on fish growth at early life stages...

Predicting chemical impact on fish growth based on modelling and in vitro cellular responses
Cellular epithelia are gate keepers that regulate the interaction of an organism with its surrounding environment...

Fish intestine as organism-environment barrier
Fish are the most frequently used vertebrates in regulatory ecotoxicology. Numerous OECD guidelines depend on the use of fish, including OECD 203...

Predicting acute fish toxicity using in vitro models
Marine mammals accumulate the greatest levels of persistent organic pollutants (POPs) due to their long life, high proportion of body fat, and top position of the marine food chain...

Humpback whale cell lines
Zellbasierte Technologien in Verbindung mit Extrapolationsmodellen erleichtern die Abschätzung der Bioakkumulation von Chemikalien und verbessern somit die Vorhersage des In-vivo-Niveaus ohne Verwendung von Tieren

Bioakkumulation von Chemikalien anhand zellbasierter Fischmodelle
Vom Menschen hergestellte Chemikalien sind zu einem wesentlichen Bestandteil unseres täglichen Lebens geworden...

Nährstoffbedarf von Fischzelllinien - Entwicklung eines serumfreien Kulturmediums (L-15Plus)

Écotoxicologie communautaire et biodiversité

PARC aims to adapt chemical risk assessment to the opportunities and needs of the 21st century.

EU PARC - Assessment of Risks from Chemicals
Des diatomées pour évaluer la pollution par les pesticides dans les eaux suisses

DIpest_CH
A multi phase research program by Eawag and the Swiss Federal Office for the Environment (FOEN)

Climate Change and Freshwater Biodiversity
Projet de recherche interdisciplinaire sur les effets biologiques des micropolluants provenant des stations d'épuration des eaux usées

EcoImpact 1
Projet de recherche interdisciplinaire sur les effets biologiques des micropolluants sur le périphyton

EcoImpact 2.0
Particulate plastics (nano- and microplastic particles; size < 5µm) are an extremely persistent pollutant in the environment. As a consequence...

Effects of particulate plastics on stream periphyton and food-webs
In order to comprehend and in the future be able to predict impacts of chemicals on aquatic biofilm communities, such as periphyton or sediment-associated biofilms...

Linking gene expression regulation by chemicals in aquatic biofilms with functional and structural alterations

Ecotoxicologie comportementale

The surfacing behavior of zebrafish larvae induced by neuroactive chemicals will be investigated on a behavioral, molecular and neuronal basis.

Impact of chemicals on surfacing behavior in zebrafish

Neurotoxic effects of insecticides in fish
Some individuals are more susceptible to chemical exposure than others, but underlying reasons remain largely obscure....

ToxPathways

Habilitation des technologies et transfert de connaissances

Implementing SSbD in practice: Integration of aquatic toxicity considerations into the R&D process for novel flame retardant vitrimers

SSbD-vitrimers
Globale und gezielte Proteomik Analysen liefern Einblicke in die molekularen Mechanismen der Toxizität.

Proteomik für Oekotoxikologie
Stellen Sie sich vor, Zellen so zu verändern, dass sie spezifische Gendeletionen oder Proteine ausgewählter Signalwege enthalten...

CRISPR-Cas9 Genommodifikation
Wir erforschen die Kapazität aquatischer Organismen und die Reaktion auf Umweltstress...

Metabolomik in Grünalgen
Im Rahmen dieses Projektes streben wir an, das Moderlieschen (Leucaspius delineatus) als Fischmodell innerhalb der Ökotoxikologie und Ökologie zu etablieren...

Moderlieschen als einheimischer Modelorganismus
Für viele Forschungsfragen ist es unabdingbar die Basiskonzentration von Nährstoffen und Spurenelementen in Modelsystemen...

Elementanalytik

Projets terminés

Für die Identifizierung und Überwachung von Chemikalieneffekten auf Organismen in der Umwelt gibt es verschiedene Ansätze...

Biomonitoring
Treatment of water by oxidation processes – Testing schemes for assessment of toxicity ...

Advanced oxidation processes
A major challenge in environmental risk assessment of micropollutants (MPs) entering fresh waters via effluents of wastewater treatment plants (WWTPs) is the establishment of a causal relationship between field exposure and observed effects on biotas...

ERAfresh
The present projects aim at gathering scientific information on the environmental fate and effects of silver- and cerium oxide nanoparticles.

Interactions of nanoparticles with algae
With the aim of developing an understanding of the impact of AgNP on food web interactions and ecological processes, we are currently using the fungal litter-decomposition and algal ...

Interactions of nanoparticles with biofilms
Do small things lead to big problems? Mechanisms of uptake and toxicity of metal nanoparticles in intestinal cells (NanoTraffic). Dr. Matteo Minghetti. PEOPLE MARIE CURIE ACTIONS ...

Interactions of nanoparticles with fish cells
One of the most important challenges in environmental toxicology is to understand how responses to chemical pollutants scale through levels of biological complexity...

Linking effects from molecules to ecosystems
The development of mathematical models for prediction of ecological risks posed by environmental chemicals requires good understanding of toxicological mechanisms.

Toxic effects on metabolism
In diesem Projekt werden GST-Enzyme in alternativen Testmodellen wie Zebrafischembryonen und Zelllinien untersucht.

GST-basierte Biotransformation in Fischen